Synthesis and antimicrobial evaluation of spiro compound containing 1,2,4-triazole and isatin
Orbital: The Electronic Journal of Chemistry
Endereço:
Av. Senador Filinto Muller, 1555
Campo Grande / MS
79074-460
Site: http://www.orbital.ufms.br
Telefone: (67) 3345-3676
ISSN: 19846428
Editor Chefe: Adilson Beatriz
Início Publicação: 28/02/2009
Periodicidade: Trimestral
Área de Estudo: Química
Synthesis and antimicrobial evaluation of spiro compound containing 1,2,4-triazole and isatin
Ano: 2011 | Volume: 3 | Número: 2
Autores: Visha P. Modi, Darshan H. Jani, Hasmukh S. Patel
Autor Correspondente: Hasmukh S. Patel | [email protected]
Autor Correspondente: Hasmukh S. Patel | [email protected]
Palavras-chave: isatin; 4H-1,2,4-triazole-4-amine; 4-R-benzoyl isothiocyanate; antimicrobial screening
Resumos Cadastrados
Resumo Inglês:
The synthesis of 6′-Phenyl-4′-thioxo-3′-(4H-1,2,4-triazole-4-yl)-3′,4′-dihydrospiro [Indoline-3,2′- 1,3,5]oxadiazine]-2-one (5a-h) is carried out by two a step reaction, beginning with acid catalyzed condensation of 4H-1,2,4-triazole-4-amine(1) with Indoline-2,3-dione (2), also called isatin, to obtain 3-(4H-1,2,4-triazole-4-ylimino)indoline-2-one (3) that on reaction with 4-(substituted)-cyclohexa-1,5-diene carbonyl isothiocyanate (4a-h) in the presence of anhydrous ZnCl2 gives targeted compounds. The compounds thus obtained, are characterized by IR, 1H NMR, 13C NMR, and elemental analysis data. The Compounds have been screened for their antimicrobial activity.