Formulation and Characterization of Gastroretentive Discs Containing Famotidine

Brazilian Archives Of Biology And Technology

Rua Professor Algacyr Munhoz Mader 3775, CIC
Curitiba / PR
Telefone: (41) 3316-3012
ISSN: 15168913
Editor Chefe: Carlos Ricardo Soccol
Início Publicação: 30/11/1946
Periodicidade: Bimestral
Área de Estudo: Biologia geral

Formulation and Characterization of Gastroretentive Discs Containing Famotidine

Ano: 2011 | Volume: 54 | Número: 2
Autores: Jignyasha Amitkumar Raval, Madhabhai M. Patel
Autor Correspondente: Jignyasha Amitkumar Raval | [email protected]

Palavras-chave: mucoadhesion, discs, gastroretentive, polyethylene oxide, polyvinylpyrrolidone

Resumos Cadastrados

Resumo Inglês:

In this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and
binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine
in the stomach. Various types of hydrophilic diluents were evaluated for their swelling and mucoadhesive property
and one (polyvinylpyrrolidone, PVP) was selected to combine with the selected mucoadhesive polymer (polyethylene
oxide, PEO). Discs with different ratios of PEO and PVP were prepared and evaluated for swelling, dissolution,
and mucoadhesion. The swelling property of the discs increased as the concentration of PEO was increased and
also did the mucoadhesion. These discs retained their integrity and adherence onto gastric mucosa for more than 10
h under in-vitro conditions. The PEO, in combination with PVP, yielded a non-disintegrating type mucoadhesive
dosage form which was suitable for gastroretentive applications to achieve the desired release profile of the drug.