ANTIFUNGAL SUSCEPTIBILITY PROFILE OF TRICHOSPORON ISOLATES: CORRELATION BETWEEN CLSI AND ETEST METHODOLOGIES

Ano: 2010 | Volume: 41 | Número: 2

Autores: Raquel M.L. Lemes, Juliana P. Lyon, Leonardo M. Moreira, Maria Aparecida de Resende

Palavras-chave: Trichosporon spp., antifungal drugs, CLSI, E-test

Resumo Inglês:

The aim of the present study was to evaluate the antifungal susceptibility profile of Trichosporon species
isolated from different sources employing the Clinical and Laboratory Standards Institute (CLSI) method
and E-test method. Thirty-four isolates of Trichosporon spp. and six CBS reference samples were tested
for their susceptibility to Amphotericin B, 5-flucytosine, Fluconazole, Itraconazole, Voriconazole and
Terbinafine. All species showed high Minimun Inhibitory Concentrations (MIC) for Itraconazole and
susceptibility to Fluconazole, The comparison among the results obtained by the CLSI method and E-test
revealed larger discrepancies among 5-flucytosine and Itraconazole. The present work provides
epidemiological data that could influence therapeutic choices. Furthermore, the comparison between
different methodologies could help to analyze results obtained by different laboratories.