Synthesis, antibacterial and antifungal activity of pyrazolyl-quinazolin-4(3H)-one derivatives
Orbital: The Electronic Journal of Chemistry
Synthesis, antibacterial and antifungal activity of pyrazolyl-quinazolin-4(3H)-one derivatives
Autor Correspondente: Navin B. Patel | [email protected]
Palavras-chave: antimicrobial activity, chalcone, pyrazole, quinazolin-4(3h)-one
Resumos Cadastrados
Resumo Inglês:
A series of pyrazolyl-quinazolin-4(3H)-ones 6a-m have been synthesized
from 2-[2-(phenylamino)phenyl]acetic acid by using efficient methods. An acid chloride
of 2-[2-(phenylamino)phenyl]acetic acid on cyclization reaction with 5-iodo anthranilic
acid yielded benzoxazinone 2, which on condensation reaction with hydrazine hydrate
afforded quinazolin-4(3H)-one 3. Acetylation of compound 3 and then condensation with
aromatic aldehydes led to the formation of chalcones 5a-m which on subjected to
reaction with phenyl hydrazine yielded the disired compounds 6a-m. All the synthesized
componds have been characterized by elemental analyses, IR and NMR spectra data. The
title compounds have been screened against bacterial as well as fungal microorganisms.
The potency of these compounds was calculated and compared with standard drugs i.e.
Penicillin-G and Fluconazole. Some of the compounds showed very good antimicrobial
activity.
